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KMID : 0613820070170010076
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Journal of Life Science
2007 Volume.17 No. 1 p.76 ~ p.81
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Inhibitory Effect of Methanol Extracts and Solvent Fractions from Meju on Mutagenicity and Growth of Human Cancer Cells
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Lim Sun-Young
Park Kun-Young
Lee Sook-Hee
Choi Jae-Sue
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Abstract
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Inhibitory effects of methanol extracts and several solvent fractions from meju on mutagenicity in vitro genotoxicity (SOS chromotest) and growth of human cancer cells (AGS gastric adenocarcinoma and Hep 3B hepatocellular cancinoma cells) were studied. The treatment of meju methanol extracts (100 ㎍/assay) to SOS chromotest system inhibited N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induced mutagenicity by 36%. However, the ethylacetate and dichloromethane fractions from meju methanol extracts showed the stronger antimutagenic effects (91% and 91%, respectively) in SOS chromotest. In sulforhodamine B (SRB) assay, the treatments of ethylacetate and dichloromethane fractions (2 ㎎/assay) significantly inhibited the growth of AGS and Hep 3B cancer cells by 64% and 71%, respectively. These results indicated that meju had inhibitory effects on MNNG in SOS mutagenic system and growth of human cancer cells, suggesting that its antimutagenic effect may be relative to activity of doenjang.
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KEYWORD
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Meju, SOS chromotest, antimutagnicity, cancer cells, sulforhodamine B(SRB) assay
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